Antioxidant and Hepatoprotective Potentials of Methanol Extract of Ficus platyphylla Stem Bark (Moraceae) in Wistar Rats

Azeez R. Sheidu1*, Zezi A. Umar1, Ahmed Abubakar2, Chindo B. Ahmed3, Magaji M. Garba1, Adogu I. Ogere4, Suleiman O. Murtala5
1Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria-Nigeria.
2Department of Pharmacognosy and Drug Development. Ahmadu Bello University, Zaria- Nigeria.
3Department of Pharmacology and Toxicology, Kaduna State University, Kaduna-Nigeria.
4Department of Histopathology, Abubakar Tafa Balewa,Bauchi-Nigeria.
5Department of Anatomy, Kogi State University, Anyigba-Nigeria.


Corresponding Author: loneumajene4real@yahoo.com; Tel: +2348035927240
Recieved Date: February 22, 2020; Accepted Date: March 25, 2020; Published Date: 30 March 2020
Citation: Sheidu AR, Umar ZA, Abubakar A, Ahmed CB, Garba MM, Ogere AI, Murtala SO. Antioxidant and Hepatoprotective Potentials of Methanol Extract of Ficus platyphylla Stem Bark (Moraceae) in Wistar Rats. Trop J Nat Prod Res. 2020; 4(3):91-97.  https://doi.org/10.26538/tjnpr/v4i3.6
Copyright: © 2020 Sheidu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Ficus platyphylla Delile has been used in Nigerian traditional medicine for the management of pain, epilepsy and inflammation. The aim of this study is to evaluate the antioxidant and hepatoprotective potentials of methanol extract of F.  platyphylla stem bark in Wistar rats. The hepatoprotective properties of methanol extract of F.  platyphylla stem bark was tested both in vitro and in vivo by evaluating oxidative stress markers, liver function parameters and changes in the morphology of liver in carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar rats. In vitro antioxidant studies of methanol extract of F.  platyphylla stem bark was evaluated using 2, 2-diphenyl-2-picryhydrazyl (DPPH) model. Treatment of Wistar rats-induced hepatotoxicity with CCl4 with methanol extract of F.  platyphylla stem bark at 100, 200 and 400 mg/kg revealed significant decrease in in vivo stress markers levels (p < 0.05, p < 0.001). Methanol extract of F.  platyphylla stems bark at doses of 100 mg/kg and 400 mg/kg significantly  reversed the increasing transaminases activities induced by the CCl4 toxicity (p < 0.05) in the Wistar rats. Histologically, there were differences in the liver morphology as compared to the control and silymarin group. These results provide scientific evidence that the liver pathology in CCl4 induced hepatotoxicity is improved by methanol extract of F.  platyphylla stem bark.

Keywords: Antioxidant, Hepatoprotective, Ficus Platyphylla, CCl4.
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