Isolation of Isosativan from Nigerian Red Propolis

Bawazeer Sami1, Henry Okoro2, Ngozichukwuka P. Igoli3, John O. Igoli2*
1College of Pharmacy, Umm Al-qura University, Makkah, Saudi Arabia.
2Department of Chemistry, University of Agriculture, Makurdi Nigeria.
3Centre for Food Technology and Research, Benue State University Makurdi Nigeria.

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Recieved Date: December 30, 2019; Accepted Date: March 28, 2020; Published Date: 30 March 2020
Citation: Sami B, Okoro H, Igoli NP, Igoli JO.  Isolation of Isosativan from Nigerian Red Propolis. Trop J Nat Prod Res. 2020; 4(3):77-79.
Copyright: © 2020 Sami et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Propolis has been known for its medicinal use and as a source of diverse bioactive natural compounds. Phytochemical screening of propolis samples usually reveal the constituent compounds and the source of the sample. Chromatography is the simplest way of isolating natural compounds and thus the hexane and ethyl acetate extracts of propolis from Bonny in Rivers State, Nigeria were subjected to column chromatography and the isolated compounds were identified by LC-MS and NMR analysis. The compounds detected and identified were oleic acid, propyl stearate, ?-amyrin, isosativan, calycosin, liquiritigenin, isoliquiritigenin, pinocembrin and medicarpin. The structure of Isosativan was further confirmed by HRMS and 2D NMR spectroscopy. This is the first report of Isosativan from a sample of Nigerian and African propolis.

Keywords: Isoflavan, ?-amyrin, Propyl stearate, Oleic acid, Rivers State.
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