Hepatoprotective and Nephroprotective Activities of Husk Extract of Zea mays Against Paracetamol-Induced Liver and Kidney Injuries In Rats

Jude E. Okokon1, John A. Udobang2, Augustine I. Bassey2, Utibe A. Edem1, Eucharia C. Agu1

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
2Department of Pharmacology and Therapeutics, Faculty of Clinical Sciences, University of Uyo, Uyo, Nigeria.

Corresponding Author: judeefiom@yahoo.com; Tel: +234-8023453678
Recieved Date: December 10, 2019; Accepted Date: March 18, 2020; Published Date: 30 March 2020
Citation: Okokon JE, Udobang JA, Bassey AI, Edem UA, Agu EC. Hepatoprotective and Nephroprotective Activities of Husk Extract of Zea mays Against Paracetamol-Induced Liver and Kidney Injuries In Rats. Trop J Nat Prod Res. 2020; 4(3):69-76.  https://doi.org/10.26538/tjnpr/v4i3.2
Copyright: © 2020 Okokon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Zea mays L (Poaceae) is used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria, inflammatory diseases and as an antidote. The husk extract of Zea mays (187-561 mg/kg) was investigated for hepato- and nephroprotective potentials against paracetamol-induced liver and kidney toxicities in rats to ascertain the folkloric claim of its usefulness in the treatment of poisoning. Assays of liver and kidney function parameters as well as histopathological study of the liver and kidney were used to assess hepatoprotective and nephroprotective activities of husk extract. Administration of the husk extract (187-561 mg/kg) caused significant (p<0.05-0.001) reductions in the levels of liver biomarker enzymes (ALT, AST, and ALP), direct and total bilirubin and elevation of serum level of total protein. The husk extract also caused significant (p<0.05) reduction of high levels of serum creatinine, urea and electrolytes concentrations (K+, Na+, Cl- and HCO3-) caused by the toxicant. The effects were dose-dependent in most cases. Histology of the liver and kidney sections of extract and silymarin-treated animals showed reductions in the pathological features compared to the organotoxic-treated animals. The biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective and nephroprotective potentials. The results showed that husk extract of Zea mays has hepatoprotective and nephroprotective potentials against injurious agents which may be due to the activities of its phytochemical components.

Keywords: Zea mays, husk,liver, hepatoprotective, nephroprotective.
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