Antimalarial Activity of Leaf Extract, Fractions and Isolation of Sterol from Alstonia boonei

Modupe M. Adeyemi1*, James D. Habila2, Thomas A. Enemakwu1, Sunday O. Okeniyi1, Labaran Salihu1
1Department of Chemistry, Nigeria Defence Academic (NDA), Kaduna State, Nigeria. 
2Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.

Corresponding Author: mmadeyemi@nda.edu.ng; Tel: +234-803 453 2419
Recieved Date: February 23, 2019; Accepted Date: August 21, 2019; Published Date: 25 August 2019
Citation: Adeyemi MM,  Habila JD, Enemakwu TA, Okeniyi SO, Salihu L. Antimalarial Activity of Leaf Extract, Fractions and Isolation of Sterol from Alstonia boonei. Trop J Nat Prod Res. 2019; 3(7):221-224.  https://doi.org/10.26538/tjnpr/v3i7.1
Copyright: © 2019 Adeyemi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Bioactive compounds in plants have found a wide application in medicines due to their pharmacological or toxicological effects in man and animals. In vitro anti-plasmodial activity of the leaves of Alstonia boonei was studied to support its traditional use as a remedy for malaria. The ethyl acetate extract was subjected to in vitro anti-plasmodial assays. The ethyl acetate extracts and fractions were found to be active against Plasmodium falciparum with percentage elimination range of 16.67 to 47.22%. The fractions were monitored using chromatographic techniques and this led to the isolation of ?-Sitosterol, a plant derived sterol. The structure of the isolated compound was elucidated using spectroscopic methods including FTIR and NMR. ?-Sitosterol has been reported to have antimalarial properties giving credence to the traditional uses of this plant for the treatment of malaria.

Keywords: Anti-plasmodial, Alstonia boonie, Leaves extracts, ?-Sitosterol.
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