Antidiabetic Activity of Pistia strateotes L.Aqueous Extract in Alloxan-induced Diabetic Rats

Mudassir Lawal1, Abdulaziz Suleiman1, Nasiruddin U. Matazu1, Fatima A. Dawud2, Aminu Mohammed3, Ismaila A. Umar1,3*
1Department of Biochemistry, Umaru Musa Yar’adua University, Katsina, Nigeria.
2Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria.
3Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria.
Corresponding Author: iaumar2003@yahoo.co.uk; Tel: +2348162060162
Recieved Date: March 11, 2019; Accepted Date: March 28, 2019; Published Date: 04 April 2019
Citation: Lawal M, Suleiman A, Matazu NU, Dawud FA, Mohammed A, Umar IA. Antidiabetic Activity of Pistia strateotes L. Aqueous Extract in Alloxan-induced Diabetic Rats.  Trop J Nat Prod Res. 2019; 3(3):91-94. https://doi.org/10.26538/tjnpr/v3i3.5
Copyright: © 2019 Lawal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Pistia strateotes L. (Araceae) commonly known as water lettuce is used traditionally for the treatment of diabetes mellitus in Nigeria. The present study was designed to validate these antidiabetic claims in alloxan-induced diabetic rats. Wister rats (weighing 150-200g) were divided into five groups of seven animals each, three of which were made diabetic by intraperitoneal injection of alloxan monohydrate (160mg/kg body weight). All rats in the diabetic groups had initial fasting blood glucose (FBG) levels ?200 mg/dL, but after treatment for three weeks with extract or glibenclamide (0.08 mg/kg body weight), the FBG significantly (p<0.05) reduced by 68.6 and 60.6%, respectively. Diabetes also caused a significant (p<0.05) elevationof serum total cholesterol (TC), triacylglycerols (TG) and low-density lipoproteins (LDL) and reduction of high-density lipoprotein (HDL)-cholesterol Treatment with P. strateotes extract (p<0.05) reverted these alterations to near normal. The serum levels of urea, creatinine, alanine transaminase (ALT), aspartate transaminase (AST), total and direct bilirubin were significantly increased above normal in untreated diabetic rats; treatment significantly (p<0.05) prevented these elevations. It is concluded that the aqueous extract of P. strateotes possesses antihyperglycaemic and hypolipidemic effects and ameliorated hepatic and renal alterations in alloxan-induced diabetic rats.

Keywords: Antidiabetic, Pistia strateotes, Diabetes, Rats.
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