Psychopharmacolgical Acitivities of Ethanol Leaf Extract of Saccharum officinarum

Jude E. Okokon1*, Anwanga E. Udoh1, Emmanuel E. Nyong2, Lekam Eno1, Nsikan M. Udo1
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,Uyo, Nigeria. 
2Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.

Corresponding Author: judeefiom@yahoo.com; Tel: +234-8023453678
Recieved Date: December 10, 2018; Accepted Date: February 11, 2019; Published Date: 01 March 2019
Citation: Okokon JE, Udoh AE, Nyong EE, EnoL, Udo NM. Psychopharmacolgical Acitivities of  Ethanol Leaf Extract of Saccharum officinarum. Trop J Nat Prod Res. 2019; 3(2):26-30.  https://doi.org//10.26538/tjnpr/v3i2.1
Copyright: © 2019 Okokon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Saccharum officinarum L. (Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol leaf extract of Saccharum officinarum (170, 340 and 510 mg/kg) was investigated for antidepressant and anticonvulsant activities in Swiss albino mice (20-25 g). Open field, force swimming and tail suspension tests were used to assess antidepressant activity, while pentylenetetrazol and aminophylline-induced convulsion models were used to assess anticonvulsant activity. The extract significantly (p<0.05-0.01) decreased the frequency of line crossing, rearing and walling activities of mice in open field test and also decreased significantly (p<0.05 - p<0.001) the duration of immobility of mice in forced swimming and tail suspension tests. The extract significantly (p<0.005 - p<0.001) offered protection against PTZ- and aminophylline-induced convulsions in mice. The findings of this study suggest that the leaf extract of S. officinarum has antidepressant and anticonvulsant activities and these supports its use in ethnomedicine for the treatment of central nervous system disorders.

Keywords: Saccharum officinarum, Anticonvulsant, Depressant, Central Nervous System.
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