Preliminary Phytochemical Evaluation and In Vitro Xanthine Oxidase Inhibitory Activity of Balanophora subcupularis P.C. Tam and Balanophora tobiracola Makino (Balanophoraceae)

Nguyen T. Tung1*, Nguyen V. Quan1, Nong P. Anh1, Nguyen V. Phuong1, Nguyen Q. Hung2
1Ha Noi University of Pharmacy, 15 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam. 
2Institute of Ecology and Biological Resources (IEBR), Vietnam Academy of Science and Technology, Hanoi, Vietnam (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam.


Corresponding Author: thanhtungng.pharmacist@gmail.com; Tel: +84975002607
Recieved Date: December 06, 2018; Accepted Date: January 21, 2019; Published Date: 04 February 2019
Citation: Tung NT, Quan NV, Anh NP, Phuong NV, Hung NQ. Preliminary Phytochemical Evaluation and In Vitro Xanthine Oxidase Inhibitory Activity of Balanophora subcupularis P.C. Tam and Balanophora tobiracola Makino (Balanophoraceae). Trop J Nat Prod Res. 2019; 3(1):6-9.  https://doi.org//10.26538/tjnpr/v3i1.2
Copyright: © 2019 Tung et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Balanophora subcupularis P.C. Tam and Balanophora tobiracola Makino are two new recently recorded species of the genus Balanophora J.R. Forst and G. Forst in Viet Nam. In the present work, we investigated the phytochemical component, in vitro xanthine oxidase (XO) inhibitory activity of methanol extracts, fractions (n-hexane and ethyl acetate) and water residue of these two species. The Thin layer chromatography (TLC) of the methanol extracts and fractions of the two species were also done. The Ethyl acetate fractions of the two species showed the best XO inhibitory activity with IC50 values of 48.41 ± 1.56 µg/mL and 11.87 ± 1.28 µg/mL for B. subcupularis and B. tobiracola, respectively. The results show that the ethyl acetate fractions of the two Balanophora species may serve as a potential source of bioactive constituent for use in the treatment of gout.

Keywords: Balanophora subcupularis, Balanophora tobiracola, xanthin oxidase, TLC.
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