Toxicological Effect of Anacardium occidentale L. Ethanol Leaf Extract on Selected Liver Function Parameters in Wistar Rats

Oluwakemi J. Awakan1,2*, Samson O. Ologba1, Oluyomi S. Adeyemi1,2, Adedoyin Igunnu3, Sylvia O. Malomo3

1Landmark University SDG 03 (Good Health and Wellbeing Research Group), Landmark University, P.M.B. 1001 Omu-Aran, Nigeria
2Department of Biochemistry, Landmark University, P.M.B. 1001 Omu-Aran, Nigeria
3Department of Biochemistry, University of Ilorin, P.M.B. 1515 Ilorin, Nigeria


Corresponding Author: amira.oluwakemi@lmu.edu.ng ; Tel: +234(0)8067865845
Recieved Date: 03 November 2020; Accepted Date: 16 September 2021; Published Date: 4 October
Citation: Awakan OJ, Ologba SO, Adeyemi OS, Igunnu A, Malomo SO. Toxicological Effect of Anacardium occidentale L. Ethanol Leaf Extract on Selected Liver Function Parameters in Wistar Rats. Trop J Nat Prod Res. 2021; 5(9):1688-1693. http://www.doi.org/10.26538/tjnpr/v5i9.26
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© 2021 Awakan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

A occidentale L. leaf extracts has been reported to possess several pharmacological properties. Although its effect on the histology of the rat liver has been ascertained, its effect on liver function parameters is yet to be fully elucidated. Therefore, this study investigated the effect of A. occidentale ethanol leaf (AOEL) extract on selected liver function. Rats were randomly distributed into four groups of five rats each: Group 1 (control group), was administered distilled water while groups 2-4 received 250, 375 and 500 mg/kg body weight of AOEL extract, respectively orally for seven days. At the end of treatments, rats were sacrificed and biochemical parameters in the liver and plasma were assessed using standard methods. AOEL extract had no significant effect on rat liver/body weight ratio but significantly (p<0.05) increased total protein and bilirubin concentrations while reducing plasma albumin concentration. AOEL extract significantly (p<0.05) reduced the activities of alanine and aspartate aminotransferases (ALT, AST) and alkaline phosphatase (ALP) in rat liver. The extract significantly (p<0.05) reduced ALT and increased gamma glutamyl transferase (GGT) activity but had no significant effect on AST and ALP activities in the plasma. AOEL extract significantly (p<0.05) decreased superoxide dismutase activity and malondiadehyde concentration in rat liver and plasma. There was no significant change in plasma glutathione concentration but its concentration increased significantly (p<0.05) in the liver. The findings suggest that A. occidentale ethanol leaf extract might have impaired liver function 

Keywords: Medicinal plants, Ethnopharmacology, Safety assessment, Liver function, Redox homeostasis, Antioxidant.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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