Homogenized Pulp and Peel Extracts of Unripe Musa paradisiaca Mitigates Castor Oil-induced Diarrhea in Rats

Ogbodo J. Onyebuchi1, Njoku U. Obioma2, Odike T. Emmanuella2, Nwodo O.C. Fred, Chibuogwu C. Christian2, Ogugofor O. Martins2

1Department of Science Laboratory Technology University of Nigeria, Nsukka, Nigeria

2Department of Biochemistry University of Nigeria, Nsukka, Nigeria




Corresponding Author: john.ogbodo@unn.edu.ng; Tel: +2348037331402
Recieved Date: 03 July 2021; Accepted Date: 04 September 2021; Published Date: 4 October
Citation: Ogbodo JO, Njoku OU, Odike TE, Nwodo OFC, Chibuogwu CC, Ogugofor MO. Homogenized pulp and Peel Extracts of Unripe Musa paradisiaca mitigates Castor Oil-induced Diarrhea in Rats. Trop J Nat Prod Res. 2021; 5(9):1677-1682. http://www.doi.org/10.26538/tjnpr/v5i9.24
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© 2021 Ogbodo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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ABSTRACT

Traditionally, Musa paradisiaca (plantain) plant parts are used for the treatment of various health disorder including diarrhoea. The study determined the effects of unripe Musa paradisiaca pulp and peel homogenates on castor oil-induced diarrhoea in Wistar rats. Twenty-eight (28) Wistar rats (100-130 g) divided into 7 groups of 4 rats each and pre-administered with the extracts prior to diarrheal induction with castor oil. Groups 1 and 2 represented the normal and standard control and received 1 mL normal saline and 3 mg/kg b.wt. of Lomotil respectively. Groups 3 and 4 were administered 200 and 400 mg/kg b.wt. of the pulp extract respectively. Groups 5 and 6 were administered 200 and 400 mg/kg b.wt. of the peel extract respectively, while rats in Group 7 received a dose of 400 mg/kg b.wt of the combined extracts. The acute toxicity result showed neither death nor toxic signs on administration of both extracts. The result also showed significant inhibition of castor oil-induced defecation frequency and stool wetness in the treated groups relative to control. The extract-treated groups also had significant increases in Na+ and K+ concentrations and a significant decrease in HCO3- concentration compared to the normal control. The result of this study affirms the antidiarrheal activity of Musa paradisiaca peels and pulp

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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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