Hypoglycemic, Hypolipidemic and Hepatoprotective Activities of Ripe and Unripe Carica papaya Methanol Extracts in Streptozotocin-Induced Diabetic Male Rats

Modupe O. Adetayo1, Adekunle M. Adetayo2, Oluwaseyi A. Adetunji1*, Titilayo F. Coker-Osiwoga1, Amaka C. Mordi1


1Department of Biochemistry, Babcock University, Ogun State, Nigeria
2Department of Surgery, Babcock University Teaching Hospital, Ogun State, Nigeria



Corresponding Author: adetunjiol@babcock.edu.ng ; Tel: 08029414423
Recieved Date: 27 May 2021; Accepted Date: 15 September 2021; Published Date: 4 October
Citation: Adetayo MO, Adetayo AM, Adetunji OA, Coker-Osiwoga TF, Mordi AC. Hypoglycemic, Hypolipidemic and Hepatoprotective Activities of Ripe and Unripe Carica papaya Methanol Extracts in Streptozotocin-Induced Diabetic Male Rats. Trop J Nat Prod Res. 2021; 5(9):1673-1676. http://www.doi.org/10.26538/tjnpr/v5i9.23
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© 2021 Adetayo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Diabetes mellitus is associated with elevated plasma glucose levels, hyperlipidemia and hepatic dysfunction. we investigated the effect of ripe and unripe Carica papaya methanol extract (CPME) on blood glucose levels, lipid profile, liver biomarker enzymes and plasma total protein in streptozotocin (STZ)-induced diabetic rats. Thirty rats were equally distributed into 6 groups: Group 1 (vehicle treated); group 2 received 500 mg/kg ripe CPME for 21 days; group 3 received 500 mg/kg unripe CPME for 21 days; group 4 received STZ (65 mg/kg once); group 5 received STZ (65 mg/kg once) and 500 mg/kg ripe CPME; group 6 received STZ (65 mg/kg once) and 500 mg/kg unripe CPME. Blood glucose was measured on days 0, 7, 14 and 21 after which animals were sacrificed and blood samples collected. Ripe and unripe CPME significantly (p<0.05) reduced plasma glucose, total cholesterol (119.78 ± 2.67 mg/dL and 113.11 ± 2.51 mg/dL), triglyceride (164.79 ± 6.19 and 135.79 ± 4.44 mg/dL), low density lipoprotein 54.71 ± 3.24 and 44.70 ± 2.89 mg/dL), very low-density lipoprotein (30.80 ± 2.79 and 28.86 ± 2.28 mg/dL), AST (60.67 ± 3.79 and 58.33 ± 1.14 U/L), ALT (56.33 ± 9.57 and 56.00 ± 8.37 U/L) and TP (7.02 ± 0.23 and 6.85 ± 0.30 g/dL) levels and significantly (p<0.05) increased high density lipoprotein (39.72 ± 4.26 and 31.44 ± 8.56 mg/dL) levels of the treated animals. Ripe and unripe C. papaya methanol extracts showed hypoglycemic, hypolipidemic and hepatoprotective activities in diabetic rats with the unripe fruit being more effective.

Keywords: Diabetes, Carica papaya, Hypoglycemic, Hypolipidemic, Hepatoprotective.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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