Evaluation of Anti-arthritic and Analgesic Activity of Celastrus paniculatus in Different Animal Models

Nishat Fatima1*, Sharoor Begum2, Michael K. Neckola3
1Department of Pharmacology, Faculty of Pharmacy and Medicine, Al Hawash Private University, Homs, Syrian Arab Republic
2Department of Pharmacology, Shadan Women’s College of Pharmacy, Khairtabad, Hyderabad-500004, Telangana, India
3Director, Research Centre, Al Hawash Private University, Homs, Syrian Arab Republic


Corresponding Author: nishat_fatima50004@yahoo.com; nishatfatima@hpu.edu.sy; Tel: 00963993115572
Recieved Date: 12 May 2021; Accepted Date: 20 August 2021; Published Date: 03 September
Citation: Fatima N, Begum S, Neckola MK. Evaluation of Anti-arthritic and Analgesic activity of Celastrus paniculatus in different Animal Models.Trop J Nat Prod Res. 2021; 5(8):1414-1421. http://www.doi.org/10.26538/tjnpr/v5i8.15
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© 2021Fatima et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

The goal of the management of arthritis is to alleviate pain, joint swelling and inflammations. Most commonly prescribed nonsteroidal anti-inflammatory agents (NSAIDs) have associated side effects on human health. The search for a novel agent is therefore essential. The study evaluated the anti-arthritic and analgesic activity of Celastrus paniculatus ethanol extract in animal models. Arthritis was induced using formalin (0.1 mL 2% v/v), while hyperalgesia by acetic acid and eddy hot plate in Wistar rats. The extracts, at 250 mg/kg and 500 mg/kg was administered to the animals for ten days. Changes in paw thickness, paw oedema volume and C-reactive protein levels were recorded. Histopathological analysis of knee joint was performed. The study results revealed that the extracts of Celastrus paniculatus significantly (p? 0.05) inhibited the increase in parameters of arthritis, inflammation and pain in a dose-dependent manner (the maximum effect was observed in 500 mg/kg body weight) and restored the normal architecture of the knee joint tissues. The study confirms the anti-arthritic and analgesic activity of Celastrus paniculatus.

Keywords: Celastru spaniculatus, formalin, anti-arthritic, C-reactive protein.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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