Shelf-Life of Formulated Herbal Liquid Dosage Forms of Picralima nitida Seed Extracts for Anti-hyperglycaemic Indication

Calistus D. Nwakile1, Ogechukwu C. Dozie-Nwakile2, Ikenna K. Uchendu2*, Vincent C. Okore3


1Department of Pharmaceutics and Pharmaceutical Technology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
2Department of Medical Laboratory Sciences, University of Nigeria, Enugu Campus, Enugu State, Nigeria
3Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria




Corresponding Author: Ikenna.uchendu@unn.edu.ng; Tel: +2347068199556
Recieved Date: 17 December 2020; Accepted Date: 12 May 2021; Published Date: 03 June
Citation: Nwakile CD, Dozie-Nwakile OC, Uchendu IK, Okore VC. Shelf-life of Formulated Herbal Liquid Dosage Forms of Picralima nitida Seed Extracts for Anti-hyperglycaemic Indication. Trop J Nat Prod Res. 2021; 5(5):932-937. http://www.doi.org/10.26538/tjnpr/v5i5.22
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© 2021 Nwakile et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Herbal remedies are widely used all over the world as alternative to conventional medicine. Picralima nitida has gained medicinal importance because of its use for treating wide range of ailments. Preliminary studies showed that its seeds and pods have hypoglycaemic effects in albino wistar rats. The aim of this study was to subject the dosage forms of the plant materials to stability studies using conventional method to establish their shelf life. The powdered dry seeds of Picralima nitida were extracted with 95% ethanol. The pod’s pulp obtained after the removal of the seeds was dried and powdered. The products were prepared into conventional dosage forms; oral solution (500 mg/kg) and suspension (500 mg/kg) were compared against standard glucose-lowering drugs, glibenclamide (0.07mg/kg) and metformin (7.20 mg/kg) for their hypoglycaemic activities. The formulations were subjected to stability studies under stress conditions of temperature. The oral solutions produced from the ethanol seed extract reduced postprandial blood glucose in the rats by an average of 14.0% within 2 h of administration. The oral suspension reduced postprandial blood glucose by an average of 29.2% within 6 h. The suspension was followed in performance by glibenclamide (24.2%), metformin (19.0%) and lastly, the oral solution of the seed extract (14.0%) in that order. The shelf-life values of the oral solution and suspension are 6.0 and 5.5 weeks respectively at 27oC. These shelf-life values are encouraging considering the herbal nature and the aqueous environment of the formulation.

Keywords: Herbal liquid dosage forms, Picralima nitida, Hypoglycaemic activity, Shelf life, Anti-hyperglycaemic activity.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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