Synthesis, Characterization and Antibacterial Activity of some Hg(II) Complexes with Mixed Benzyl 2-(2-oxoindolin-3-ylidene) Hydrazinecarbodithioate and Phosphines or Amines Ligands

Mahmood M. Salih1, Ahmed A. Irzoqi 1*, Yuosra K. Alasadi2, Montazer K. Mensoor

1Department of Chemistry, College of Education for Pure Science, University of Tikrit, Tikrit Iraq
2Department of Biology, College of Education for Pure Science, University of Tikrit, Tikrit Iraq
3International Center for Training, Research & Development (ICTRD), Baghdad, Iraq


Corresponding Author: ahmed2irzoqi@gmail.com; Tel: +9647702061755
Recieved Date: 12 March 2021; Accepted Date: 24 May 2021; Published Date: 03 June
Citation: Salih MM, Irzoqi AA, Alasadi YK, Mensoor MK. Synthesis, Characterization and Antibacterial Activity of some Hg(II) Complexes with Mixed Benzyl 2-(2-oxoindolin-3-ylidene) Hydrazinecarbodithioate and Phosphines or Amines Ligands. Trop J Nat Prod Res. 2021; 5(5):895-901. http://www.doi.org/10.26538/tjnpr/v5i5.17
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© 2021 Salih et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Isatin-derived schiff bases with S-dithiocarbazate ester and their complexes are increasingly important for antibacterial activity, so new Hg complexes were prepared with benzyl 2-(2-oxoindolin-3-ylidene) hydrazinecarbodithioate (BHT) and diphosphines (dppm, dppe, dppp and dppb) or amines (bipy, phen). The phosphine complexes have the given formulas [Hg2(BHT)2µ(dppm)2]Cl4 , [Hg(BHT)(diphosphine)Cl]Cl (diphosphine; dppm, dppe), while the amine complexes have the formulas; [Hg(BHT)(amines)]Cl2. The prepared complexes have been characterized by molar conductivity, elemental analysis, FTIR, 31P-NMR and 1H-NMR. Furthermore, this study concludes the evaluation of biological activity of prepared complexes against three bacterial species Staphylococcus Epidermidis and Staphylococcus aureus (gram positive) and Citrobacer Freundii (gram negative) by Agar well method where the antibiotic Amikacin used as a comparison material, prepared complex [Hg(BHT)(bipy)]Cl2 showed activity against Staphylococcus aureus more than  amikacin, while the [Hg2(BHT)2µ(dppe)2]Cl4, [Hg(BHT)(bipy)]Cl2 and [Hg(BHT)(Phen)]Cl2 complexes showed activity against Staphylococcus Epidermidis more than  amikacin, the [Hg2(BHT)2µ(dppe)2]Cl4, [Hg(BHT)(dppb)]Cl2, [Hg(BHT)(bipy)]Cl2 and [Hg(BHT)(Phen)]Cl2 complexes showed activity against Citrobacter freundii more than amikacin in the minimum concentration.

Keywords: Isatin, Dithiocarbazide, Mercury complexes, Diphosphines, Biological activity.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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