Antibacterial and Synergistic Effects of Extracts of Allium cepa, Allium sativum, Zingiber officinale and Garcinia kola on Selected Bacterial Strains

Chukwudi I. Nnamchi1*, Val E. Okefum1, Christian D. Amaechi2, Kenneth Ugwu1, Chijoke A. Nsofor3
1Department of Microbiology, University of Nigeria, Nsukka, Nigeria
2Department of Pharmaceutical Microbiology, University of Nigeria, Nsukka, Nigeria
3Department of Biotechnology, Federal University of Technology, Owerri, Nigeria



Corresponding Author: chukwudi.nnamchi@unn.edu.ng ; Tel: +2348037461157
Recieved Date: 30 January 2021; Accepted Date: 09 April 2021; Published Date: 03 May
Citation: Nnamchi CI, Okefum VE, Amaechi CD, Ugwu U, Nsofor CA. Antibacterial and Synergistic Effects of Extracts of Allium cepa, Allium sativum, Zingiber officinale and Garcinia kola on Selected Bacterial Strains. Trop J Nat Prod Res. 2020; 5(4): 763-771. doi.org/10.26538/tjnpr/v5i4.28 http://www.doi.org/10.26538/tjnpr/v5i4.28
Copyright:
© 2021 Nnamchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Tropical Journal of Natural Product Research




ABSTRACT

For a return to nature and the fighting powers of many natural products against infections as solutions. Therefore, this study was aimed at investigating the phytochemical, antibacterial and synergistic potency of the extracts of some of these natural plants viz.: Allium cepa, Allium sativum, Zingiber officinale and Garcinia kola against some selected bacterial strains which are sometimes used in antimicrobial resistance studies: Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. Qualitative phytochemical analysis of the extracts showed that they contain varying amounts of alkaloids, flavonoids, glycosides, tannins, saponins and steroids. Aqueous, ethanol and hexane extracts of the plants were used in the investigations against the test microorganisms. Results obtained showed that the microorganisms were highly susceptible to the aqueous and ethanol extracts, but showed comparatively less susceptibility to hexane extracts which were mainly oily components. Compared to the other test strains, K. pneumoniae showed the most resistance to the extracts. Combinations of the extracts showed positive synergism as they produced higher antimicrobial effects on many of the organisms. The minimum inhibitory concentration (MIC) ranged from 25mg/mL to 200mg/mL. Aqueous extracts of the plants produced the lowest MIC value of 25mg/mL against most of the bacteria. Considering the increasing failure of conventional antibiotic therapies, the results of this study could be positive indications that natural plants, spices and foods could serve as possible alternatives or options in the management of many infections.

Keywords: Antimicrobials, Medicinal plants, Minimum Inhibitory Concentration (MIC), Phytochemicals, Synergism.
Back to Articles

ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
Scopus citescore 0.3 (2020)

Indexing & Abstracting

citescore 0.3 (2020)

j-gate logo

International Innovative Journal Impact Factor

African Index Medicus

CAS

Index Copernicus International

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Crossref Content Registration logo

WorldCat Discovery Service

Geneva Foundation for Medical Education and Research