Effect of Lactobacillus acidophilus and Lactobacillus plantarum on Weight Reduction in Obese Rats

Cecilia K. Okediya1*, John O. Oyewale1, Theresa T. Okediya2, Ayodeji S. Ajayi1, Grace I. Olasehinde1
1Department of Biological Sciences, Covenant University Ota, Ogun State, Nigeria
2Department of Computer Science, Covenant University, Ota, Ogun State, Nigeria

Corresponding Author: okediyacecilia@gmail.com; Tel: +2347030319542
Recieved Date: 19 January 2020; Accepted Date: 18 April 2021; Published Date: 03 May
Citation: Okediya CK, Oyewale JO, Okediya TT, Ajayi AS, Olasehinde GI. Effect of Lactobacillus acidophilus and Lactobacillus plantarum on Weight Reduction in Obese Rats. Trop J Nat Prod Res. 2021; 5(4): 759-762. doi.org/10.26538/tjnpr/v5i4.27 http://www.doi.org/10.26538/tjnpr/v5i4.27
© 2021 Okediya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Obesity is a risk factor for diseases such as high blood pressure and type 2 diabetes. Over the years, alternatives to the use of drugs and surgery being used to treat obesity are being sought to improve health. This research aimed to determine the effect of two Lactobacillus spp on weight reduction in obese rats. Fifty 6-8weeks old female albino Wistar rats were grouped into two major groups; High fat diet (HFD) groups and Normal Diet (ND) groups. A concentration of 1 x 109 cfu/ml of the Lactobacillus spp was suspended daily in normal saline and orally given to rats for two weeks. The weights of both obese and non-obese rats were recorded. Results were analysed using the one-way analysis of variance. Results indicated that body weight increased more in the HFD groups compared to the ND groups. Analysis after probiotic treatments showed that L. plantarum (P1), and L. acidophilus + L.plantarum (PMIX) were effective in reducing the weight of the obese rats (P<0.05) while L. acidophilus (P2) was ineffective at reducing weight gain in the obese groups. The use of probiotics for weight loss can limit the adverse side effect associated with using conventionally produced anti-obesity drugs.

Keywords: Obesity, Probiotics, Weight, High Fat Diet, Lactobacillus. 
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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