Curative Effect of Aqueous Seed Extract of Citrus paradisi against Carbon Tetrachloride-Induced Nephrotoxicity in Wistar Rats

 Olagunju J. Abayomi1, Akinola O. Oyewole2*, Joseph A. Olagunju1, Olusegun O. Akinola2*, Omolola E. Omotosho2

1Department of Medical Biochemistry, Lagos State University College of Medicine, Ikeja-Lagos, Nigeria
2Department of Biochemistry, Covenant University, P.M.B 1023, Km 10, Idiroko road, Canaan land,Ota, Ogun State, Nigeria

Corresponding Author: ; Tel: +2348169157828
Recieved Date: 03 November 2020; Accepted Date: 15 April 2021; Published Date: 03 May
Citation: Abayomi OJ, Oyewole AO, Olagunju JA, Akinola OO, Omotosho OE. Curative Effect of Aqueous Seed Extract of Citrus Paradisi against Carbon Tetrachloride-Induced Nephrotoxicity in Wistar Rats. Trop J Nat Prod Res. 2021; 5(4): 749-752.
© 2021 Abayomi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Carbon tetrachloride (CCl4) is a possible nephrotoxin that leads to grievous and harmful chemical toxicity. C.paradisi contains phytochemicals,vitamins and flavonoids which possesses strong anti-inflammatory, and antioxidant properties. This study investigated the serum electrolytes levels and the efficacy of C. paradisi to ameliorate the effect of carbon tetrachloride-induced nephrotoxicity in Wistar rats. The aqueous seed extract of C. paradisi was administered at a dose of 125-500 mg/kg body weight. Thirty albino rats were assigned into 6 groups of 5 rats in each. Group I was the 1ml/kg normal saline while group II was intraperitoneally treated with 3 mL/kg of CCl4 1 hour before oral treatment (p.o.) with 10 mL/kg of normal saline while groups III-VI rats were intraperitoneally treated with 3 mL/kg 30% CCl4 1 hour before oral treatment with 10 mg/kg of ascorbic acid. Groups III-VI were administered with 125 mg/kg, 250 mg/kg, and 500 mg/kg of aqueous seed extract of C.paradisi. Results shows an increase in all the serum electrolytes except in serum phosphate as a result of contamination. The result insinuated that kidney damage was induced in the rats with ascorbic acid attenuating the effect of carbon tetrachloride at each dose. The treatment showed that aqueous seed extract of C. paradisi controls an increase in serum electrolytes.

Keywords: Nephrotoxicity, Carbon tetrachloride, Serum electrolytes, Citrus paradisi, Toxicology.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
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