Influence of Lophira lanceolata Leaf Extract on Reproductive Indices and Hematological Parameters in Male Wistar Rats

Olajumoke O. Nwaechefu1*, Oluwatosin A. Arojojoye1, Tolulope A. Oyedeji2, Oluwatoyin O. Ojo3, Olubunmi A. Balogun4, Simbiat Kassim1

1Department of Biochemistry, Lead City University, Ibadan, Nigeria
2Department of Biochemistry, University of Lagos, Nigeria
3Department of Chemical Sciences, Anchor University Lagos, Nigeria
4Department of Anatomy, Bowen University, Iwo, Osun State, Nigeria

Corresponding Author:; Tel: +2348037450936
Recieved Date: 07 September 2020; Accepted Date: 10 April 2021; Published Date: 03 May
Citation: Nwaechefu OO, Arojojoye OA, Oyedeji TA, Ojo OO, Balogun OA, Kassim S. Influence of  Lophira lanceolata Leaf Extract on Reproductive Indices and Hematological Parameters in Male Wistar Rats. Trop J Nat Prod Res. 2021; 5(4): 744-748.
© 2021 Nwaechefu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Lophira lanceolata is a medicinal plant used in folk medicine for the treatment of toothache, liver infections, cough, fever and heart pains. Currently, the patronage of medicinal plants as an alternative to synthetic drugs has increased. This present study aim to investigate the effects of L. lanceolata leaf extract on reproductive indices, haematological parameters and serum biochemical parameter in male Wistar rats. Mature rats weighing 200-220g, n= 5 per group were administered L. lanceolata extract (100, 200 and 300 mg/kg body weight) by oral gavage for 21 days. The cauda epididymal sperm count, motility, morphology, livability and hematological parameters were assessed by standard procedures. The levels of testosterone, alanine aminotransferase (ALT), aspartate aminotransferase (AST) were determined spectrophotometrically. Formalin-fixed, H&E stained tissues were examined using a light microscope. The results showed that administration of 100, 200 and 300 mg/kg body weight of L. lanceolata extract decreased the sperm count significantly (p< 0.05) by 27, 36 and 38% and the sperm motility by 50, 47 and 80% respectively. The percentage abnormality also increased by 10, 31 and 17% respectively. Similarly, histopathological changes were observed in the testes of rats orally administered L.lanceolata extract. However, there were no significant changes in the haematological indices and activities of AST, ALT and ALP compared to control. This study showed that L. lanceolata had adverse effects on male reproductive parameters but had no effects on haematological indices and liver enzyme activities.  Therefore, the extract should be administered with caution.

Keywords: Lophira lanceolata, Testes, Testosterone, Sperm count.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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