Antimicrobial Activity and Phytochemical Analysis of Some Selected Plants against Clinical Pathogens

1Microbiology Unit, Department of Pure and Applied Biology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
2Department of Biochemistry, College of Science and Technology, Covenant University, PMB 1023, Canaan land, Ota Ogun State, Nigeria  


© 2021 Bamigboye et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Corresponding Author: coadegunlola@lautech.edu.ng; Tel: +2348037450936
Recieved Date: 25 August 2020; Accepted Date: 24 March 2021; Published Date: 03 May
Citation: Bamigboye CO, Fatoki IO, Yakubu OF, Biodun R. Antimicrobial Activity and Phytochemical Analysis of Some Selected Plants against Clinical Pathogens. Trop J Nat Prod Res. 2021; 5(4): 732-738. doi.org/10.26538/tjnpr/v5i4.22 http://www.doi.org/10.26538/tjnpr/v5i4.22
Copyright:
Copyright: © 2021 Bruce et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Tropical Journal of Natural Product Research




ABSTRACT

Plants have been used since ancient times, both as food and medicine, with different plant parts having different antimicrobial potency. This study aimed at assessing the antimicrobial potentials of different metabolites contained in the leaves of Momordica charantia, Nicotiana tabacum, Ocimum gratissimum, and Calotropis procera against clinical isolates. The isolates tested were Escherichia coli, Pseudomonas aureginosa, Staphylococcus aureus,  Proteus mirabilis, Klebsiella pneumoniae, and Candida albicans. Selected extracts were analyzed for their phytochemical contents and further with Gas chromatography-mass spectrometry (GC-MS). The methanol extracts of M. charantia, N. tabacum, and O. gratissimum were effective against the clinical isolates. In contrast, the isolates were resistant to the methanol extract of C. procera and the water extracts of all plants under study. Methanol extracts of M. charantia, N. tabacum, and O. gratissimum contained anthocyanins. The GC-MS analysis revealed the presence of 1-methyl-2-phenylbenzylmidazole, 4-phenyl-pyridopyrimidine in M. charantia, tetradecamethyl cycloheptasiloxane in N. tabacum, and 3,4-dimethoxycinnamic acid in O. gratissimum. It was concluded that leaves of M. charantia, N. tabacum, and O. gratissimum could be explored for pharmaceutical applications.

Keywords: Antimicrobial, Gas Chromatography-Mass Spectrometry, Momordica charantia, Nicotiana tabacum, Phytochemical.
Back to Articles

ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
Index Copernicus Value (ICV) for 2017: 59.83
Scopus citescore 0.3 (2020)

Indexing & Abstracting

citescore 0.3 (2020)

j-gate logo

International Innovative Journal Impact Factor

African Index Medicus

CAS

Index Copernicus International

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Crossref Content Registration logo

WorldCat Discovery Service

Geneva Foundation for Medical Education and Research