Antioxidant, Antibacterial and Antiplasmodial Activities of Galactogogue Plant Extracts 

Rattanapron Traisathit1, Aphidech Sangdee2, Komgrit Wongpakam3, Sutthira Sedlak3, Phongthon Kanjanasirirat4, Suparerk Borwornpinyo4, Thanyapit Thita5, Rapatbhorn Patrapuvich5, Prapairat Seephonkai1*

1Nanotechnology Research Unit, Department of Chemistry, Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand, and Center of Excellence for Innovation in Chemistry (PERCH-CIC)
2Microbiology and Applied Microbiology Research Unit, Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand
3Walairukhavej Botanical Research Institute, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand
4Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
5Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand

Corresponding Author: prapairat.s@msu.ac.th; Tel: 6643754246
Recieved Date: 16 February 2021; Accepted Date: 24 March 2021; Published Date: 03 May
Citation: Traisathit R, Sangdee A, Wongpakam K, Sedlak S, Kanjanasirirat P, Borwornpinyo S, Thita T, Patrapuvich R, Seephonkai P. Antioxidant, Antibacterial and Antiplasmodial Activities of Galactogogue Plant Extracts. Trop J Nat Prod Res. 2021; 5(4): 698-706. doi.org/10.26538/tjnpr/v5i4.18 http://www.doi.org/10.26538/tjnpr/v5i4.18
Copyright:
© 2021 Traisathit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Galactogogue plants have been used traditionally worldwide to stimulate lactation. Research on antioxidant, antibacterial and antimalarial activities of the galactogogue plants are limited to a few of its species. Thus, this work aims to evaluate in vitro antioxidant (2,2-diphenyl-1-picrydydrazyl (DPPH) radical and 2,2´-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging abilities, ferric reducing antioxidant power (FRAP), total phenolic content (TPC) and total flavonoid content (TFC)), and also antibacterial and antimalarial activities of sixteen galactogogue plants collected from northeastern Thailand. The antioxidant, antibacterial and antimalarial assays followed established procedures. Results indicated that the methanol and ethyl acetate extracts from the stem bark of Caesalpinia sappan (CS) and Ochna integerrima (OI) showed potent antioxidant capacity with the DPPH, ABTS and FRAP assays. These two particular plant extracts also possessed high TPC and moderate TFC. Both extracts of CS also exhibited good antibacterial activity, followed by extracts from OI which showed selective antibacterial activity toward three Gram-positive bacteria. The ethyl acetate extract from the stem bark of Siphonodon celastrineus (SCe), and the methanol and ethyl acetate extracts of Micromelum minutum (MM) also displayed strong antiplasmodial activity against Plasmodium falciparum. Our findings suggest that both CS and OI could be used as potential natural antioxidant and antibacterial (especially against Gram-positive bacteria) sources while MM and SCe could be promising alternative antimalarial plant for treating the P. falciparum parasites.

Keywords: Antioxidant activity, Antibacterial activity, Antimalarial activity, Galactogogue
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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