Vanillin Modulates the Status of Glycoconjugates in Favouur of Tumor Suppression in 7,12dimethylbenz[a]anthracene Induced Oral Carcinoma in Golden Syrian Hamster

Insha Naseer1, Chakkaravarthy Elanchezhiyan1*, Shanmugam Manoharan2, Towseef Hassan1, Mani Neelakandan2
1Department of Zoology, Annamalai University, Tamil Nadu, India
2Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India


Corresponding Author: cheziyan6@gmail.com; Tel: +919865815558
Recieved Date: 04 February 2021; Accepted Date: 17 April 2021; Published Date: 03 May
Citation: Naseer I, Elanchezhiyan C, Manoharan S, Hassan T, Neelakandan M. Vanillin Modulates the Status of Glycoconjugates in Favour of Tumour Suppression in 7,12dimethylbenz[a]anthracene Induced Oral Carcinoma in Golden Syrian Hamster. Trop J Nat Prod Res. 2021; 5(4): 617-620. doi.org/10.26538/tjnpr/v5i4.4 http://www.doi.org/10.26538/tjnpr/v5i4.4
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 © 2021 Naseer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ABSTRACT

Vanillin (4-hydroxy-3-methoxybenzaldehyde), the major component of natural vanilla has been reported to show antimicrobial, anti- inflammatory, hepatoprotective and anticarcinogenic activities. In this study, the modulatory efficacy of vanillin on plasma and buccal mucosa glycoconjugates has been investigated in 7,12dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral tumors were induced in the hamsters buccal pouch using 0.5% DMBA, in liquid paraffin (topical application, three times a week for 14 weeks). Plasma and buccal mucosa glycoconjugates status were assessed colorimetrically in the experimental hamsters. While the glycoconjugates status was found to be abnormal in both the plasma and buccal mucosa, vanillin administration orally at the dose of 200 mg/kg b.w to hamsters treated with DMBA revertedtheglycoconjugates status to near normal concentration. The results obtained clearly exhibited the protective effect of vanillin on the cell surface and circulatory glycoconjugates in DMBA induced oral carcinoma.

Keywords: Oral cancer, Vanillin, DMBA, Glycoconjugates, Hamster.
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ISSN: 2616-0684 (Print)
ISSN: 2616-0692 (Online)
DOI: 10.26538/tjnpr
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