Antioxidant Compound of Endophytic Fungi Penecillium oxalicum Isolated from Swietenia mahagoni L. Jacq

Fadhillah Fadhillah1, Elfita Elfita2*, Muharni Muharni2, Heni Yohandini2, Hary Widjajanti3
1Magister Program of Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Palembang, South Sumatra, 30662 Indonesia.
2Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Inderalaya, Ogan Ilir, South Sumatra, 30662 Indonesia
3Department of Biology, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Inderalaya, Ogan Ilir, South Sumatra, 30662 Indonesia


Corresponding Author: elfita.elfita.69@gmail.com; Tel: +62 852-7974-5106
Recieved Date: 22 January 2021; Accepted Date: 18 March 2021; Published Date: 03 March
Citation: Fadhillah F, Elfita E, Muharni M, Yohandini H, Widjajanti H. Antioxidant Compound of Endophytic Fungi Penecillium oxalicum Isolated from Swietenia Mahagoni L. Jacq. Trop J Nat Prod Res. 2020; 5(3):543-548. doi.org/10.26538/tjnpr/v5i3.20 http://www.doi.org/10.26538/tjnpr/v5i3.20
Copyright:
© 2021 Fadhillah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Endophytic fungi are microorganisms that are symbionts in plant tissues. Endophytic fungi isolated from medicinal plants such as S. mahagoni may produce a plethora of bioactive compounds. In this study, endophytic fungi was isolated from the leaves of S. mahagoni and cultivated in potato-dextrose broth (PDB) for six weeks at static condition. The antioxidant compound was isolated from the ethyl acetate extract of endophytic fungi by chromatographic method, and the chemical structure was determined by spectroscopic analysis. The antioxidant activity was tested by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the endophytic fungi was analyzed to identify its species by molecular method. Based on the spectroscopic analysis (1H-NMR, 13C-NMR, HMQC, and HMBC spectra), the antioxidant compound was identified as mono-o-methylcurvilinic acid with IC50 of 38.01 µg/mL. Phylogenetic analysis showed the endophytic fungi as Penicillium oxalicum.

Keywords: Antioxidant compound, Endophytic fungi, Penicillium oxalicum, Swietenia mahagoni.
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