The Altered Efficacy of Traditional Antidiabetic Formulations in Chittagong Division: Metformin Admixing

Sumaiya Nahid1*, Trissa Saha2, Ruhul Amin3, Md. Atiar Rahman4, Akif Md. Thousif1, Afsara T. Chowdhury1, Md. Zafar A. Sadiq2, Abul B. M. Faroque5


1Department of Pharmacy, University of Science and Technology Chittagong, Foys Lake, Pahartali, Chittagong-4202, Bangladesh
2Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories, Rajshahi, binodpur bazar, Rajshahi-6206, Bangladesh
3Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-i-Khuda Road, Dhanmondi, Dhaka-1205, Bangladesh
4Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, Bangladesh
5Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Nilkhet Rd, Dhaka-1000, Bangladesh






Corresponding Author: sumaiya.nahid@ustc.ac.bd; Tel: +8801812737870
Recieved Date: 6 February 2021; Accepted Date: 13 March 2021; Published Date: 03 March
Citation: Nahid S, Saha T, Amin R, Rahman MDA, Thousif AKMD, Chowdhury AT, Sadiq MDAS, Faroque ABM. The Altered Efficacy of Traditional Antidiabetic Formulations in Chittagong Division: Metformin Admixing. Trop J Nat Prod Res. 2021; 5(3):453-459. doi.org/10.26538/tjnpr/v5i3.7 http://www.doi.org/10.26538/tjnpr/v5i3.7
Copyright:
© 2021 Nahid et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ABSTRACT

Traditional medicine describes the treatment of diseases using a traditional medicinal practitioner’s plant-based prescriptions. Although most people in developing countries continue to rely on traditional medicinal practices, many practitioners add modern active pharmaceutical ingredients (APIs) to their formulations. The aim of this study was to investigate the inclusion of metformin, an antidiabetic API, in traditional formulations, which represents a departure from standard practice. Samples were collected based on reports obtained from a short survey of practitioners in Chittagong City (Samples A, B, C, E, and F) and Rangamati District (Samples D, H, I, and J). The presence of metformin in the collected traditional formulations was confirmed using reversed-phase high-performance liquid chromatographic (HPLC) analysis comparing against a metformin standard. The HPLC chromatograms indicated the adulteration of the traditional medicine Samples D, E, I, and J with metformin, whereas the Samples A, B, C, F, and H were devoid of metformin admixture. The Samples D, E, I, and J contained 0.2169 ± 0.0018 ppm, 1.0714 ± 0.01 ppm, 2.8311 ± 0.01 ppm, and 0.0309 ± 0.003 ppm metformin, respectively. Inappropriate doses of metformin added to traditional medicines have been reported to result in detrimental health effects for patients. These results demonstrated the intentional use of metformin in traditional antidiabetic drugs by traditional practitioners to increase their credibility, which could represent a risk to the safety of patients who depend on traditional medicine.

Keywords: Traditional medicine, Metformin, High Performance Liquid Chromatography, Antidiabtic, Adulterant.
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