Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review

Hanna Goenawan1 Yuni S. Pratiwi1 Nararian P. Dewi2*, Achadiyani Achadiyani3 Nova Sylviana1
1Physiology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
2Faculty of Medicine, Padjadjaran University, Bandung, Indonesia
3Cell Biology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia

Corresponding Author: nararian17001@mail.unpad.ac.id; Tel: +62-82-24492-5906
Recieved Date: 12 January 2021; Accepted Date: 13 March 2021; Published Date: 03 March
Citation: Goenawan H, Pratiwi YS, Dewi NP, Achadiyani A, Sylviana AN. Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review. Trop J Nat Prod Res. 2021; 5(3):420-433. doi.org/10.26538/tjnpr/v5i3.2 http://www.doi.org/10.26538/tjnpr/v5i3.2
Copyright: © 2021 Goenawan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Lycopene has received a lot of attention because of its benefits in various chronic diseases such as cancer, cardiovascular, neurodegenerative, and metabolic diseases such as diabetes. Various studies using cell culture, animals, and humans as subjects have proven the benefits of lycopene in diabetes, but none have yet explained its molecular mechanism in detail. Therefore, this study aims to summarize and describe the benefits of lycopene in diabetes mellitus and the potential underlying mechanisms. This study is a literature review that uses articles obtained from the PubMed and Google Scholar databases by entering the keywords lycopene, diabetes, oxidative stress, inflammation, apoptosis, and autophagy either separately or in combination to obtain a logical concept. There are 33 main articles summarized and discussed in this study. Lycopene shows potential use in the therapy and prevention of diabetes complications, particularly through its antioxidant and anti-inflammatory activities. Lycopene also increases insulin signalling activity via the PI3K/AKT pathway. Moreover, lycopene supplementation contributes to decreasing apoptosis in brain cells and weakens apoptosis in podocytes through the autophagy process. Knowing these benefits, lycopene supplementation in diabetics needs to be considered, but further research is needed in the form of large clinical trials to prove the benefits of lycopene in diabetes and the optimal dosage required.

Keywords: Lycopene, Diabetes, Oxidative stress, Inflammation, Apoptosis, Autophagy.
Back to Articles