A Mini Systematic Review: Eucheuma cottonii, a Red Algae, as a Radiosensitizer?

Tisa P. Putri¹, Ida A.T.K. Dewi¹, Tiara B.M. Permata¹, Endang Nuryadi¹, Henry Kodrat¹, Heri Wibowo², Melva Louisa³, Soehartati A. Gondhowiardjo¹*

¹Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia 

²Diagnostic and Research Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

³Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Corresponding Author: gondhow@gmail.com; Tel: (021) 3921155

Recieved Date: September 19, 2020; Accepted Date: January 26, 2021; Published Date: 03 February 2021

Citation: Putri TP, Dewi ITK, Permata TBM, Nuryadi E, Kodrat H, Wibowo H, Louisa M, Gondhowiardjo SA. A Mini Systematic Review: Eucheuma cottonii, a Red Algae, as a Radiosensitizer? Trop J Nat Prod Res. 2021; 5(1):7-15.  https://doi.org/10.26538/tjnpr/v5i1.2

Copyright: © 2021 Putri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

Radiosensitizers assist radiotherapy in providing greater tumor inactivation. Currently there is a search for natural radiosensitizer components which are expected to provide lesser side effects than chemical radiosensitizers. Eucheuma cottonii is a plant with antioxidant and anti-tumor effects. This review aims to search for the potential use of Eucheuma cottonii as a radiosensitizer. This is a mixed review study, where the main component is a systematic review and then followed by a narrative review. This review suggests that Eucheuma cottonii has the potential to become a radiosensitizer, by interfering with the cell cycle control mechanisms and reactivation of p53. Further research is needed to explore the synergistic effect of the combined use of radiotherapy and Eucheuma cottonii.