Physicochemical Assessment and Drug Potential of Some Phenylpropanoid and Flavonoid Compounds of Ethyl Acetate Eluate from Umudike Propolis

Sylvester N. Ugariogu1,2*, Ijeoma A. Duru1, Fidelis C. Onwumere1, John O. Igoli3
1Chemistry Department Federal University of Technology Owerri, Nigeria
2Africa center of Excellence in future energies and electrochemical system (ACE-FUELS) Federal university of Technology, Owerri, Nigeria
3Chemistry Department Federal University of Agriculture Makurdi, Nigeria

Corresponding Author: mastersylvester@yahoo.com; Tel: +2348067614917
Recieved Date: October 20, 2020; Accepted Date: December 24, 2020; Published Date: 02 January 2021
Citation: Ugariogu SN, Duru IA, Onwumere FC, Igoli JO. Physicochemical Assessment and Drug Potential of Some Phenylpropanoid and Flavonoid Compounds of Ethyl Acetate Eluate from Umudike Propolis. Trop J Nat Prod Res. 2020; 4(12): 1208-1214.  https://doi.org/10.26538/tjnpr/v4i12.30
Copyright: © 2020 Ugariogu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Propolis is a natural product produced from bees which have been acclaimed a medicinal product. In this study, greenish propolis samples collected from a private apiary in Umudike of Abia State, Nigeria were subjected to column chromatography using ethyl acetate as solvent. The eluates that were soluble in ethyl acetate only was subjected to liquid chromatography–mass spectrometry (LC-MS) and the result was analyzed using MestReNova (Mnova) software to identify and match the chemical compositions present in the eluate from some already isolated compounds from Propolis in Africa. The following compounds; 2-methyl-2-butenyl (E)-caffeate, Prenyl caffeate or 3-methyl-2-butenyl caffeate, 3-methyl-3-butenyl-(E)-caffeate, isosativan, calycosin, liquiritigenin, naringenin, eupatolitin, acacetin, quercetin, galangin and medicarpin were identified to be present in the sample and they were matched with their structure, matching score, percentage purity and retention time. Drug-like properties of the matched compounds were determined using the computed physicochemical properties from the Mnova software. The result showed the presence of some known compounds which have been used in medicinal chemistry and drug synthesis.

Keywords: Propolis, Physicochemical, Drug-like properties, Phytochemicals, LC-MS, Mnova.
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