Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

Emeka E. J. Iweala1*, Eunice O. Bankole1, Franklyn N. Iheagwam1,2, Omoremime E. Dania1, Ujowundu F. Ntite3
1Department of Biochemistry, Covenant University, PMB 1023, Ota, Ogun State, Nigeria
2Covenant University Public Health and Wellbeing Research Cluster (CUPHWERC), Covenant University, PMB 1023, Ota, Ogun State, Nigeria
3Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria

Corresponding Author: emeka.iweala@covenantuniversity.edu.ng; Tel: +2348036738625
Recieved Date: July 28, 2020; Accepted Date: December 16, 2020; Published Date: 02 January 2021
Citation: Iweala EEJ, Bankole EO, Iheagwam FN, Dania OE, Ntite UF. Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines. Trop J Nat Prod Res. 2020; 4(12): 1143-1146.  https://doi.org/10.26538/tjnpr/v4i12.18
Copyright: © 2020 Iweala et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

Cancer is associated with the unregulated multiplication of cells in specific parts of the body. Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were ? 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell lines.

Keywords: Xylopia aethiopica, Cell viability, MDA-MB-231, LNCaP, Medicinal plants, Cancer.
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