Nephroprotective Potential of Alpha Lipoic Acid in 5-Fluorouracil-Induced Toxicity of Wistar Rats

Jamal-Deen I. Tiiba1, Mohammed G. Magaji1, Nuhu M. Danjuma1, Abdulai B. Sallau2
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Nigeria
2Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Nigeria

Corresponding Author: jamaltiba@yahoo.com; Tel: +2348089243661
Recieved Date: July 13, 2020; Accepted Date: December 16, 2020; Published Date: 02 January 2021
Citation: Tiiba JDI, Magaji MG, Danjuma NM, Sallau AB.  Nephroprotective Potential  of  Alpha  Lipoic  Acid  in  5-Fluorouracil-induced  Toxicity  of  Wistar  Rats. Trop J Nat Prod Res. 2020; 4(12): 1139-1142.  https://doi.org/10.26538/tjnpr/v4i12.17
Copyright: © 2020 Tiiba et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

5-Fluorouracil is a widely used anticancer drug but its therapeutic potential is limited due to its nephrotoxic and hepatotoxic side effects. This study was therefore designed to study the protective effects of Alpha Lipoic Acid (ALA) in 5-Fluorouracil-induced nephrotic damage in Wistar rats.  Intraperitoneal injection of 50 mgkg-1 of 5-FU was associated with significant (p ? 0.05) increases in the urea, uric  acid, creatinine, and potassium  levels.  However, intraperitoneal injection of 50 mgkg-1 of 5-FU was associated with significant (p ? 0.05) decrease in  the  sodium and magnesium  levels in the  toxicity model control when compared with untreated control rats. Pretreatment and posttreatment with  ALA attenuated these changes. This is indicative  of  the  nephroprotective  potential  of  ALA  in  5-FU-induced kidney injury.

Keywords: Alpha Lipoic Acid, 5-Fluorouracil, Kidney, Wistar rats.
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