Chemical Study, Antioxidant Capacity, and Hypoglycemic Activity of Malva pseudolavatera Webb & Berthel and Malva sylvestris L. (Malvaceae), Grown in Ecuador

Glenda M. Sarmiento-Tomalá1, Migdalia Miranda-Martínez2*, Yamilet I. Gutiérrez-Gaitén3, René Delgado-Hernández4,5
1University of Guayaquil. Faculty of Chemical Sciences. "Salvador Allende" University Citadel. Ave. Kennedy S / N and Av. Delta. Guayaquil. Ecuador. 
2Escuela Superior Politécnica del Litoral, ESPOL, Department of Chemical and Environmental Sciences. Faculty of Natural Sciences and Mathematics, Campus Gustavo Galindo Km. 30.5 Vía Perimetral, P.O. Box 09-01-5863. Guayaquil, Ecuador
3Department of Pharmacy, Institute of Pharmacy and Food, University of Havana, Coronela, Lisa, Habana 13600, Cuba 
4Center for Biological Research and Evaluations. University of Havana, Coronela, Lisa, Havana 13600, Cuba. 
5Faculty of Exact, Natural and Agricultural Sciences, University of Santander, (UDES), Bucaramanga, Santander, Colombia.

Corresponding Author:; Tel: +593 988408956
Recieved Date: September 28, 2020; Accepted Date: December 28, 2020; Published Date: 02 January 2021
Citation: Sarmiento-Tomalá GM, Miranda-Martínez M, Gutiérrez-Gaitén YI, Delgado-Hernández R. Chemical Study, Antioxidant Capacity, and Hypoglycemic Activity of Malva pseudolavatera Webb & Berthel and Malva sylvestris L. (Malvaceae), Grown in Ecuador. Trop J Nat Prod Res. 2020; 4(12):1064-1071.
Copyright: © 2020 Sarmiento-Tomalá et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Malva pseudolavatera and M. sylvestris (Malvaceae) are two species in great demand in Ecuador for their medicinal virtues. However, the chemical and biological information on M. psudolavatera is scarce. The present study aims to carry out a comparative chemical study of the antioxidant and hypoglycemic activities of the leaves of the species M. pseudolavatera and M. sylvestris to justify their traditional use. Extracts were made with 80% hydroalcoholic mixture from the leaves of M. sylvestris and M. pseudolavatera. The chemical composition was analyzed by Liquid chromatography coupled to mass spectrometry. The antioxidant capacity was performed by the Ferric Reducing Antioxidant Power, 2,2-diphenyl-1-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid techniques and the hypoglycemic activity in Wistar rats at the doses of 250, 500 and 1000 mg/kg, of the extracts, were evaluated. Liquid chromatography coupled to mass spectrometry analysis allowed the detection of similarities and differences in the chemical composition of both leaf extracts, the flavonoid gosipetin 3-O-?-D-glucopyranosyl-8-O-?-D-glucuronopyranoside, was found in both species and for M. pseudolavatera is reported for the first time.  The extract of M. sylvestris showed antioxidant capacity and hypoglycemic activity, superior to the extract of M. pseudolavatera. The results of this research report for the first time the phenolic and flavonoid composition, as well as the antioxidant and hypoglycemic activity of the extracts of the leaves of M. pseudolavatera and its comparison with that of M. sylvestris for which there were previous reports.

Keywords: Antioxidant activity, Hypoglycemic activity, Liquid chromatography, Malva species.
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