Medicinal Plants as Recent Complementary and Alternative Therapy for COVID-19: A Review

Dewa A. A. S. Laksemi1*, Dewa M. Sukrama2, Made Sudarmaja1, Putu A. A. Damayanti1Kadek Swastika1, Ni L. P. E. Diarthini1, Nyoman M. Astawa3, Ketut Tunas4
1Department of Parasitology, Faculty of Medicine, Udayana University, Jl PB Sudirman Denpasar 80234, Bali, Indonesia 
2Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Jalan PB Sudirman, Denpasar, Bali, Indonesia
3Veterinary Virology Laboratorium Faculty of Veterinary Udayana University, Jalan PB Sudirman Denpasar, 80234, Bali, Indonesia
4Management of Health Information Department, Bali International University, Jl Seroja gg Jeruk ,Tonja, Denpasar 80234, Bali, Indonesia

Corresponding Author: srilaksemi@unud.ac.id; Tel: +62 81392017107
Recieved Date: October 07, 2020; Accepted Date: December 17, 2020; Published Date: 02 January 2021
Citation: Laksemi DAAS, Sukrama DM, Sudarmaja M, Damayanti PAA. Swastika K, Diarthini NLPE. Astawa NM, Tunas K. Medicinal Plants as Recent Complementary and Alternative Therapy for COVID-19: A Review. Trop J Nat Prod Res. 2020; 4(12): 1025-1032.  https://doi.org/10.26538/tjnpr/v4i12.1
Copyright: © 2020 Laksemi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT

The World Health Organization stated COVID-19 became a pandemic since March 11, 2020. With the absence of a vaccine and standard treatment for Covid-19 infection, individual protection including maintaining personal hygiene, consumption of food, vegetables and fruit that can increase immunity is the key to preventing COVID-19. The combination of herbs and modern therapy can contribute to lower mortality rates and a faster response in controlling outbreaks. This review is aimed to determine plants that have effect on coronavirus infection, mechanism of action, dosage, toxic effect, thus can be beneficial for strengthening health against covid-19. This research is a literature review that search articles using Google Scholar, ResearchGate, NCBI, PubMed, Web of Science and Semantic Scholar, used a combination keywords related to coronavirus or COVID-19, SARS CoV-2, herb, natural compound, mechanism of action, dosage, toxic effect, meta-analysis, review. Curcuma longa, Cinnamon, Glycyrrhizin, Kaempferia galanga, Eucalyptus essential oil, black tea, were plants that have pieces of evidence as anti-coronavirus. The molecular mechanism of these plants as anti-virals varies by inhibiting entry, blocking viral receptors, inhibiting enzymes, enhancing immune system, interfering with signal transduction, relief symptoms.  Therefore, plant products used in the right dose could be beneficial against coronavirus infection.

Keywords: Anti-viral agents, COVID-19, Medicinal plants, Mechanism of action, Molecular, SARS-CoV.
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